In the case of Bediol, the mixed THC/CBD cannabis chemovar, the blood levels of THC were about 50% higher than expected from the administered THC dose. Moreover, a similar effect was observed in a psychopharmacological study conducted with healthy cannabis users at the University of Sydney, in which higher THC levels were found in the blood of subjects who received cannabis containing equal amounts of THC and CBD, than in the case of cannabis containing an equal dose of THC, but without CBD.
The exact mechanism by which this effect occurs is still not clear. Possible explanations include an increased absorption of THC in the lungs or the inhibition of THC metabolism, both induced by CBD, or the conversion of CBD into THC. In any case, knowledge of these pharmacokinetic THC-CBD interactions can help physicians and patients in establishing a proper therapeutic dose of cannabis to treat their symptoms. Further research is needed to confirm this, however it is possible that lower doses of THC are required when co-administering it with CBD, in order to achieve symptom control of a particular disease.