In general, patients seem to tolerate medicinal cannabis well: the possible side effects are transient (last a short time), mostly benign, and resolve as tolerance builds. When properly administered, medicinal cannabis does not have toxic or harmful effects on patient health.
Unwanted side effects mainly occur after the intake of high doses, or when medicinal cannabis is used in combination with other substances that increase its effects (e.g. alcohol or particular medications).
Research regarding expected adverse effects of cannabis use in a therapeutic context is limited. Consequently, a significant amount of data on this issue is derived from studies investigating recreational cannabis use, which implies caution in formulating conclusions regarding medicinal use. Specifically, the amount of cannabis used, the methods of delivery and the existence of comorbidies significantly differ between the recreational and medicinal cannabis user populations. As a result, different adverse effects might be expected.
Bedrocan’s medicinal cannabis is quality controlled by an external, internationally certified laboratory. The results of the analysis of every batch are presented in a Certificate of Analysis (CoA). This level of quality assurance shows our products to be free of harmful contaminants.
When cannabis of unknown origin is used, there is always a chance the product is contaminated with pesticides, growth enhancers, heavy metals or microbes. These contaminants are very damaging to the health of a patient.
Moreover, using standardised medicinal cannabis products is critical to ensuring the same dose is taken each time. This reduces the risk of overdosing and consequently that of unwanted side effects.
A review of the effects of the medicinal use of cannabinoids indicated that the most frequent categories of adverse effects relate to respiratory, gastrointestinal, and nervous system disruptions.
The common acute side effects of high doses of cannabis occur quickly after consumption, including:
In general, all side effects are transient. They should slowly decrease and then disappear within a few hours.
Preventing side effects
Most unwanted side effects from the administration of medicinal cannabis may be prevented by adopting the following guidelines:
A special warning:
Patients with a hereditary risk of psychosis or other psychiatric conditions (e.g. schizophrenia or depression), and patients with cardiac/coronary conditions should avoid the use of cannabis and cannabinoids, as they may potentiate these conditions.
Preventing getting ‘high’
When using larger doses of medicinal cannabis, a user may experience a ‘high’ – a mild intoxication, best described as a mild euphoria or an experience of distorted reality (which can culminate in a mild anxiety). The main component of cannabis, the cannabinoid THC, is responsible for these psychoactive effect.
The chance of experiencing these effects is greater when medicinal cannabis is consumed orally, because the digestive system releases THC-metabolites – chemicals even more psychoactive than THC itself. This is one of the reasons why edibles commonly lead to problems with overdosing.
When consuming cannabis in the form of tea (a liquid, which is easier to digest) such side effects occur less frequently. Patients susceptible to psychosis are advised to use the cannabis variety Bediol, as CBD has been shown to be capable of suppressing the psychoactive effects of THC.
Most often, the feeling of being ‘high’ is experienced as a mild euphoria – the feeling of being happy and energised. As time passes, this changes to feelings of deep content and relaxation. Some individuals may experience mild impairment of short-term memory, an increase in heart rate, uncontrolled laughter, and changes in the awareness of their surroundings (colours, sounds). With large doses, mild visual and auditory hallucinations may occur. In a recreational setting, these symptoms are mostly mild and appreciated. For inexperienced users or after the consumption of high doses these symptoms can result in acute feelings of anxiety. In these cases, most often, it is sufficient to sit or lay down in a calm and comfortable location, preferably with someone familiar to talk to. If there is an experience of an unwanted ‘high’, this can usually be prevented by consuming less medicinal cannabis, or by administering the dose slowly over a longer period.
Just like any other medicine, medicinal cannabis is not totally harmless. The most important risk factors are briefly discussed below.
On rare occasions, cannabis use can induce a state of psychosis in individuals with a genetic predisposition. As a result, patients with a (family) history of psychotic disorders, particularly schizophrenia and bipolar disorder, should be under careful psychiatric monitoring when using medicinal cannabis. Moreover, a short, acute psychotic like episode (anxiety and depression) is possible in the case of non-predisposed individuals, especially when very high doses of THC is taken.
Occasionally, new scientific reports appear on the effects of cannabis on risk of psychosis. However, a direct link between cannabis and psychosis has not yet been established. The discourse surrounds the question: does cannabis induce psychosis in otherwise totally healthy individuals, or does pre-existing genetic vulnerability for psychosis result in adverse outcomes from cannabis use?
Recent scientific studies into this matter suggest a small proportion of the population has genetic predispositions that increase the risk of developing chronic psychotic symptoms when using cannabis (as a medicine or otherwise).
Cannabinoids can have a strong, but temporary, effect on heart rate and blood pressure. Patients with a history of heart disease or receiving medication for heart disease should avoid their use, or only use cannabis under careful supervision by a medical doctor.
The use of cannabis during pregnancy is likely to affect the development of the fetus. Because certain components of cannabis – including THC – are excreted in breast milk, the use of medicinal cannabis is also not advised while breastfeeding.
After cannabis administration, the liver is the main organ involved in chemically altering the cannabinoids as part of its function to process and excrete external substances by the body (metabolism).
The effects of cannabis may therefore be significantly different in patients with a liver disease. Therefore, these patients should be monitored during initiation to ensure the dose taken does not exceed the liver’s capacity to metabolise.
The evidence suggests that the risk of developing an addiction to cannabis when taken as a medicine is minimal. The recommended dose for medicinal use is often lower than that of a recreational user, and a medical professional should always be involved in medicating and monitoring the patient.
Patients should take particular care, however, if they have prior problematic substance use. High doses of medicinal cannabis, taken over long periods, may lead to dose escalation and misuse. The abrupt cessation (quitting) may then cause withdrawal symptoms, such as mild forms of restlessness, irritability, insomnia, vivid dreams, and decreased appetite.
The consumption of medicinal cannabis has not been shown to lead to life threatening adverse events, even at very high doses. However, an overdose of cannabis (THC) can result in a range of adverse effects, with high variability in tolerance between subjects. The most common adverse effect of overdosing a single dose of THC is anxiety, which, in some cases, may lead to mild acute psychotic states (panic attacks). In addition, increased heart rate and changes in blood pressure may occur.
Specifically, it is possible that THC overdosing will result in acute hypotension and/or tachycardia. In some cases, nausea and vomiting and diarrhea may be observed as well. That aside, impaired executive function and motor control may lead to feelings of confusion, depersonalisation, loss of control, or even helplessness. Also reddened eyes and a dry mouth may be experienced as very unpleasant to some individuals. Most adverse effects will spontaneously resolve, usually within a few hours, when serum levels of THC fall.
There are suggestions that in a small number of cases THC is capable of precipitating psychosis, involving delusions and hallucinations. If these side effects occur, they seem to be rare, because they most likely require very high doses of THC administered over a prolonged periode of time, or a pre-existing genetic vulnerability. However, there is enough reason to be cautious and communicate these risks in a fair and balanced way.